viral latency การใช้

• This is in contrast to viral latency, a form of dormancy in which the virus does not replicate.
• Although it can prevent the establishment of viral latency, acyclovir therapy has not proven effective at eradicating latent viruses in nerve ganglia.
• This included preventing infection and viral latency in 92 % of animals vaccinated and a reduction in recurrent legions by 64 % and viral shedding by 53 %.
• Ataxia telangiectasia mutated ( ATM ) is a kinase that ( similar to mTOR ) can phosphorylate KAP1 resulting in the switch from viral latency to the lytic cycle.
• While viral latency exhibits no active viral shedding nor causes any pathologies or symptoms, the virus is still able to reactivate via external activators ( i . e . sunlight, stress ) to cause an acute infection.
• After infection, the virus enters into lymphocytes via macropinosomes where it remains in a latent ( " quiet " ) state expressing the viral latency-associated nuclear antigen, LANA . The virus exists as a naked circular piece of DNA called an episome and uses the cellular replication machinery to replicate itself.